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Halozyme Therapeutics Presents Preclinical and Pharmacokinetic Data on the Subcutaneous Delivery of Antibodies With Enhanze Technology at the 2006 IBC Antibody Conference

02 Jun 2006

CORONADO, CA, USA | Jun 01, 2006 | Halozyme Therapeutics, Inc. (Amex: HTI), a biopharmaceutical company developing and

commercializing recombinant human enzymes, today presented new pharmacokinetic and preclinical studies of the company's Enhanze Technology (rHuPH20) platform for the subcutaneous (underneath the skin) delivery of antibody therapeutics at the IBC Drug Discovery Antibody Conference.

Studies evaluating the pharmacokinetics and tolerability of several subcutaneously injected antibody candidates with and without rHuPH20 in different animal models were presented. The results demonstrated significant increases in peak blood levels and a more rapid appearance in the bloodstream of antibody candidates injected subcutaneously with rHuPH20 compared to subcutaneous injections alone.

"The self-administration of antibodies by patients is evolving as the method of choice for chronic antibody therapies," said Gregory Frost, PhD, Halozyme's Vice President and Chief Scientific Officer. "A large number of monoclonal antibody therapies in development could potentially be converted from intravenous to subcutaneous administration with rHuPH20."

Halozyme's rHuPH20 is a highly purified, recombinant form of the naturally occurring human enzyme and is being investigated for its ability to break down hyaluronic acid (HA), the space-filling "gel"-like substance that is a major component of tissues throughout the body. Use of hyaluronidase may potentially change the route of administration or improve the bioavailability of new antibody therapies.

About Halozyme Therapeutics, Inc.

Halozyme is a biopharmaceutical company developing and commercializing recombinant human enzymes for the drug delivery, palliative care, oncology, and infertility markets. The company's portfolio of products is based on intellectual property covering the family of human enzymes known as hyaluronidases. Halozyme's recombinant human enzymes may replace current animal slaughterhouse-derived extracts that carry potential risks of animal pathogen transmission and immunogenicity. The company has received FDA approval for two products: Cumulase(R), the first and only recombinant human hyaluronidase for cumulus removal in the IVF process; and Hylenex, for use as an adjuvant to increase the absorption and dispersion of other injected drugs. The versatility of the first enzyme, rHuPH20, enables Halozyme to develop the product as a medical device, drug enhancement agent, and therapeutic drug.

Safe Harbor Statement

In addition to historical information, the statements set forth above include forward-looking statements (including, without limitation, statements concerning pre-clinical data, the potential effectiveness of products under development, the timing and nature of clinical trials for products under development, and the demand and potential market for these products, if approved by the FDA) that involve risk and uncertainties that could cause actual results to differ materially from those in the forward-looking statements. The forward-looking statements are also identified through use of the words "believe," "enable," "may," "will," "could," "intends," "estimate," "anticipate," "plan," "predict," "probable," "potential," "possible," "should," "continue," and other words of similar meaning. Actual results could differ materially from the expectations contained in forward-looking statements as a result of several factors, including regulatory approval requirements and competitive conditions. These and other factors that may result in differences are discussed in greater detail in the company's reports on Forms 10-KSB, 10-QSB and other filings with the Securities and Exchange Commission.

Halozyme Contact Investor Relations Contacts
David A. Ramsay Zachary Bryant
Chief Financial Officer Lippert/Heilshorn & Associates
(858) 794-8889 (310) 691-7100
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Media Contacts
Kathy Sweeney / Joleen Schultz
Mentus
858-455-5500, x230/x215
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SOURCE: Halozyme Therapeutics, Inc

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