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Scientific presentation at the 99th annual meeting of the American Association for Cancer Resarch (AACR)
TORONTO, CANADA | April 16, 2008 | Lorus Therapeutics Inc. (“Lorus”) (TSX: LOR; AMEX: LRP), a biopharmaceutical company specializing in the research, development and commercialization of pharmaceutical products and technologies for the management of cancer, today announced presentations of further preclinical data from its two lead anticancer drugs at the Annual Meeting of the AACR in San Diego, CA, April 12-16, 2008.
The first presentation titled, “Preclinical development of LOR-253, a novel anticancer drug candidate that functions by modulating intracellular labile zinc homeostasis leading to cell cycle arrest,” will be presented on April 16, 2008.
In this presentation, Lorus provided data on the preclinical development of LOR-253 (formerly known as LT-253), the Company’s lead anticancer small molecule, with a novel cellular target. In animal studies, LOR-253 showed a favorable pharmacokinetic profile following intravenous dosing. A key finding of the study was the tissue distribution of LOR-253, where the drug was detected in tumor tissues in animal models, with significant affinity for lung and colon tissues. These results strongly support the potential treatment of these cancers with LOR-253, which has shown selective and potent anticancer activity in animal models of non-small cell lung cancer and colon cancer.
LOR-253 is currently in IND-enabling GLP toxicology studies, which are to be completed by mid-2008. Planning of a Phase I clinical trial in cancer indications for LOR-253 is in progress.
The second presentation, presented on April 13, 2008 titled, “GTI-2040 displays cooperative anti-tumor activity, when combined with chemotherapeutics and immunotherapeutics against human renal carcinoma xenografts”.
This study reported preclinical results from combination therapies with GTI-2040, which is now known as LOR-2040. The data showed that LOR-2040 significantly improved the anticancer efficacy of an important group of cytokine immunotherapeutic agents, including interferon alpha and interleukin-2, which have been used in the treatment of solid tumors. The findings expand the potential avenues for development of LOR-2040.
“We are pleased to be able to present and discuss our findings at the AACR annual meeting”, commented Dr. Aiping Young, President and CEO of Lorus. “These studies show our continued commitment to high quality preclinical research that is in-line with our ongoing clinical programs and corporate strategy”.
About LOR-2040
LOR-2040 is a DNA-based drug that specifically targets the R2 component of ribonucleotide reductase, which is required for DNA synthesis and cell proliferation. R2 has also been described as a malignant determinant that is elevated in a wide range of tumors, and through down regulation can cooperate with a variety of cellular cancer causing genes known as oncogenes to enhance tumor growth and metastatic potential. Currently, LOR-2040 is in seven clinical studies, including a Phase II trial in AML, Phase I in MDS and Acute Leukemias, and five Phase I/II trials in solid tumors.
About LOR-253
LOR-253 is a small molecule compound that has shown selective and potent antitumor activity in a variety of human cancers, including colon cancer and non-small cell lung cancer, and has an excellent therapeutic window due to its low toxicity. The mode of action of LOR-253 involves the downregulation of cyclin D1, an important regulator of cell cycle progression and cell proliferation, and induction of the tumor suppressor Kruppel like factor 4 (KLF-4). Alterations in KLF-4 expression and the cyclin D1 regulatory pathway have been linked to the development of cancer.
About Lorus
Lorus is a biopharmaceutical company focused on the research and development of novel therapeutics in cancer. Lorus’ goal is to capitalize on its research, preclinical, clinical and regulatory expertise by developing new drug candidates that can be used, either alone, or in combination with other drugs, to successfully manage cancer. Through its own discovery efforts and an acquisition and in-licensing program, Lorus is building a portfolio of promising anticancer drugs. Lorus Therapeutics Inc. is listed on the Toronto Stock Exchange under the symbol LOR, and on the American Stock Exchange under the symbol LRP.
SOURCE: Lorus Therapeutics Inc. |
